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the treatment of major depressive disorder and became available in the United States in early 2014. Here is key information about this medication. Please see THIS PAGE for a handout listing both the common and less common side effects of this medication along with the percentages of patients who report them. 3. It is recommended that doses of 20 mg/day and 15 mg/day be reduced to 10 mg/day for one week prior to discontinuing treatment, if possible. 4. Do not use MAOIs with or within 21 days of stopping treatment with Trintellix. Do not use Trintellix within 14 days of stopping MAOI. 5. With strong inhibitors of CYP2D6, consider dosage reduction of Trintellix by half. 6. If strong CYP inducers are coadministered for 14 days, consider increasing the dose of Trintellix (up to 3 times maximum). Vortioxetine is available as immediate release tablets of 5 mg, 10 mg, and 20 mg. The dose range is 5 to 20 mg/day. The usual starting dose is 10 mg/day. The dose should be increased to 20 mg/day if needed and tolerated. For patients who are known to be cytochrome P450 2D6 poor metabolizers, the maximum dose should be 10 mg/day. The Prescribing Information says that vortioxetine can be given without regard to meals, the significance of that is to know that its absorption is not affected by food. But in my opinion, as with other antidepressants, it is best to advise the patient to take vortioxetine after food because its most common adverse effect is nausea. In April 2020, the cost of 30 pills of vortioxetine 10 mg or 20 mg was $375 (source: goodrx.com). So the 10 mg and 20 mg pills cost the same. At this time, the real clinical significance of its multiple receptor effects is not known. Vortioxetine is one more addition to our armamentarium and one more option for the treatment of major depressive disorder. But, in my opinion, it has not been convincingly shown that it has any significant advantage over cheap, generic antidepressants. Copyright 2015 to 2020, Simple and Practical Medical Education, LLC. All rights reserved. May not be reproduced in any form without express written permission. Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information.